Mystery Case: Balo concentric sclerosis

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Mystery case: Baló concentric sclerosis.

A 45-year-old man presented with progressive Broca aphasia and right hemiparesis. MRI demonstrated a large white matter lesion with multiple rings (figure). These centrifugal rings reflect concentric layers of active demyelination, typical for Baló concentric sclerosis. CSF showed oligoclonal bands and a mild pleocytosis. Partial recovery followed 5 days of treatment with IV methylprednisolone ...

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Pathognomonic MR imaging findings in Balo concentric sclerosis.

Irregular, concentric zones of increased signal on T2-weighted cranial MR imaging studies may strongly suggest Balo concentric sclerosis (BCS), a rare but recognized variant of multiple sclerosis. Differentiating BCS from multiple sclerosis or neoplasm can be difficult clinically, but MR imaging findings noted in this case may be pathognomonic.

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Balo's concentric sclerosis.

1. Medical student, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands, 2. Department of Radiology, St. Elizabeth Hospital, Tilburg, The Netherlands, 3. Department of Neurology, Maxima Medisch Centrum Veldhoven, Veldhoven, The Netherlands Background: A 46-year-old woman was admitted with right-sided weakness, vertigo and nausea. Clinical examinatio...

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Hypoxia-like tissue injury and glial response contribute to Balo concentric lesion development

OBJECTIVE To clarify the pathogenic factors and mechanisms underlying the development of concentric demyelinating lesions in Balo disease. METHODS We conducted serial clinical, MRI, and histopathologic assessments of concentric lesion formation in a case of relapsing Balo disease. RESULTS The patient experienced 2 attacks caused by left parietal and left frontal lesions in 5 years. In MRI f...

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Pitfalls in the diagnosis of a tumefactive demyelinating lesion: A case report

INTRODUCTION In rare instances, demyelinating disorders manifest as tumefactive lesions that simulate brain tumors. We report a patient with a space-occupying lesion in the parietal lobe, which presented a serious diagnostic dilemma, between a rare tumefactive demyelinating disease, such as Balo concentric sclerosis and a glioma. This case report highlights important diagnostic clues in the dif...

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ژورنال

عنوان ژورنال: Neurology

سال: 2013

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0b013e3182824e7d